Saliva (oral) drug tests are very donor friendly, non-invasive and easy to collect the specimen. Saliva drug testing tends to detect very recent drug use. Also these drug tests are harder to adulterate than the urine drug tests since the sample can be obtained under direct supervision.

A disadvantage of saliva based drug testing is that it is not approved by SAMHSA for use with DOT / Federal Mandated Drug Testing. While oral fluid in not considered a bio-hazard unless there is visible blood, it should be treated with care.